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Chunk #35 — Discussion

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Developmental change in regional brain structure over 7 months in early adolescence: comparison of approaches for longitudinal atlas-based parcellation.
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A number of factors can affect image quality and registration accuracy and ultimately increase measurement error. Church et al. (Church et al., 2010) reviewed problems of head size differences and movement in the scanner as common problems to overcome in acquisition and analysis. They note, for example, that although children have smaller heads and tend to move more in the scanner than adults, these problems can be minimized by registering brains of all ages (especially those at least 7 years old) to a common atlas. This approach also enables direct comparison of children and adults, at least within the older child/young adolescent to adult age range (Burgund et al., 2002). In the current study, we used the SRI24 atlas (Rohlfing et al., 2010) constructed from adult MRI data to register the adolescent MRI data, collected in 10 to 13 year olds, into common space, thus abiding one of the recommendations to minimize error from subject movement. In addition, we calculated SNR in the MRIs for each registration approach and found adequate SNR for each method that was not related to