Our study used a large general population sample with EHR-derived data for the first time in BP GWAS. The consistency and generalizability of BP genomics findings from one-time research-protocol-based assessments to purely clinical measures recorded in an EHR has been questioned36. We were able to replicate most previously-identified loci from many cohorts using research-based assessments, demonstrating BP genetic findings are not significantly different between studies using research assessments and those using clinical, EHR-derived ones. This is important because clinical measures recorded in the EHR are the basis for clinical decisions in general, real-world, clinical practice. Moreover, this extends GWAS reach to numerous clinical samples.
