Technically, heritability is first estimated on the observed scale, namely dichotomous OCD diagnosis; however, heritability on the continuous liability scale is more interpretable and so is usually reported. Heritability can be transformed from the observed to the continuous liability scales because they are functions of prevalence (30). To determine how sensitive our heritability estimate was to prevalence, we varied it between 0.5%−3% and found heritability to vary between 25%−38% (Supplementary Materials Table S4).
