hippocampal neural progenitor cells was found in APPKM670/671NL/PS1L166P mice post onset of deposition (Ermini et al., 2008). Several additional studies examined hippocampal neurogenesis in transgenic mice coexpressing FAD-linked APP and PS1 mutant variants. Thus, for example, in APPswe/PS1ΔE9 mice, a decrease in long-term survival of hippocampal progenitors was detected post onset of deposition (Verret et al., 2007). Long-lasting impairments in hippocampal neurogenesis were detected in APP/PS1 KI mice post onset of deposition (Zhang et al., 2006). Taniuchi and colleagues report a decrease in the number of proliferating cells and of newly-formed neuronal (DCX+) cells in the hippocampus of APPswe/PS1ΔE9 mice at age of 9 months, post amyloid deposition, but not at onset of deposition (5 months) (Taniuchi et al., 2007). In 3×Tg-AD, an age- and gender-dependent reduction in proliferation of hippocampal progenitor cells correlates with number of hippocampal neurons accumulating intracellular Aβ (Rodriguez et al., 2008).
