The correlation between neuroticism and substance use was smaller than the correlation between neuroticism and internalizing psychopathology (.29 versus .98). A Wald test was used to test whether the pathway from neuroticism to the internalizing psychopathology factor was different than the pathway from neuroticism to the substance use factor; this test was significant, χ2 (1)=20.3, p < .0001. As predicted, higher-order neuroticism was more strongly related to internalizing disorders than to substance use disorders.
