Neuroticism as a common dimension in the internalizing disorders.
paper
Cited
Public
- Authors
- Griffith, J W; Zinbarg, R E; Craske, M G; Mineka, S; Rose, R D; Waters, A M; Sutton, J M
- Year
- 2010
- Journal
- Psychological medicine
- PMID
- 19903363
- DOI
- 10.1017/S0033291709991449
- PMCID
- PMC2882529
BACKGROUND: Several theories have posited a common internalizing factor to help account for the relationship between mood and anxiety disorders. These disorders are often co-morbid and strongly covary. Other theories and data suggest that personality traits may account, at least in part, for co-morbidity between depression and anxiety. The present study examined the relationship between neuroticism and an internalizing dimension common to mood and anxiety disorders. METHOD: A sample of ethnically diverse adolescents (n=621) completed self-report and peer-report measures of neuroticism. Participants also completed the Structured Clinical Interview for DSM-IV (SCID). RESULTS: Structural equation modeling showed that a single internalizing factor was common to lifetime diagnosis of mood and anxiety disorders, and this internalizing factor was strongly correlated with neuroticism. Neuroticism had a stronger correlation with an internalizing factor (r=0.98) than with a substance use factor (r=0.29). Therefore, neuroticism showed both convergent and discriminant validity. CONCLUSIONS: These results provide further evidence that neuroticism is a necessary factor in structural theories of mood and anxiety disorders. In this study, the correlation between internalizing psychopathology and neuroticism approached 1.0, suggesting that neuroticism may be the core of internalizing psychopathology. Future studies are needed to examine this possibility in other populations, and to replicate our findings.
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| Name | Type |
|---|---|
| 11th year students local | cohort |
| acute stress disorder local | phenotype |
| adolescents | cohort |
| adolescent sample | cohort |
| adults | cohort |
| agoraphobia | phenotype |
| alcohol | phenotype |
| alcohol dependence | phenotype |
| Alcohol Use | phenotype |
| alcohol use disorders | phenotype |
| antisocial personality disorder | phenotype |
| anxiety | phenotype |
| behavioral inhibition | phenotype |
| Big 5-N local | drug |
| Big 5-N local | phenotype |
| BIS | phenotype |
| cannabis dependence | phenotype |
| cannabis use | phenotype |
| Cognitive style local | phenotype |
| college students | cohort |
| comorbid anxiety and depression local | phenotype |
| comorbid mood and anxiety disorders local | phenotype |
| Comorbid mood and anxiety disorders local | phenotype |
| conduct disorder | phenotype |
| Current disorders local | phenotype |
| depression | phenotype |
| DSM syndromes local | phenotype |
| dysthymia | phenotype |
| Emotion | phenotype |
| emotion regulation | phenotype |
| externalizing disorders | phenotype |
| extraversion | phenotype |
| generalized anxiety disorder | phenotype |
| Goldberg's neuroticism scale local | phenotype |
| Graduate students local | cohort |
| High-neuroticism participants local | cohort |
| hyperarousal | phenotype |
| Internalizing core local | phenotype |
| Internalizing disorder factor local | phenotype |
| internalizing disorders | phenotype |
| IPIP | drug |
| IPIP-N local | drug |
| IPIP-N local | phenotype |
| Krueger et al. (2001) study local | cohort |
| Lifetime disorders local | phenotype |
| Low-neuroticism participants local | cohort |
| major depressive disorder | phenotype |
| Medium-neuroticism participants local | cohort |
| mood disorders | phenotype |
| National Comorbidity Survey | cohort |
| negative affect | phenotype |
| NEO | phenotype |
| neuroticism | phenotype |
| neuroticism factor | phenotype |
| Neuroticism (peer-report) local | phenotype |
| neuroticism scales local | phenotype |
| Neuroticism (self-report) local | phenotype |
| NOS diagnosis local | phenotype |
| obsessive-compulsive disorder | phenotype |
| panic disorder | phenotype |
| participants | cohort |
| peers | phenotype |
| personality disorders | phenotype |
| personality traits | phenotype |
| positive affect | phenotype |
| Postdoctoral fellows local | cohort |
| posttraumatic stress disorder | phenotype |
| psychiatric outpatients local | cohort |
| psychopathology | phenotype |
| psychosis | phenotype |
| Questionnaire packet local | phenotype |
| research assistants | cohort |
| rumination | phenotype |
| Screening questionnaire local | phenotype |
| social phobia | phenotype |
| specific phobia | phenotype |
| substance use | phenotype |
| twin children and adolescents local | cohort |
| Virginia Twin Registry | cohort |
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