Consistent with the SNP‐based findings, PRKG2 was significant for Cz alpha power (p = .019). In addition, LOC101928942 reached significance (p < .019). This gene is an antisense noncoding RNA gene embedded in PRKG2. Both Cz and occipital alpha power showed a cluster of significant genes at 3p21 ranging from (hg19) basepair positions 52234203 to 52728499 (ALAS1 to GLT8D1). For Cz alpha power, 17 of these genes were significant discoveries at q = .05. For occipital alpha power, 11 genes reached significance of which 4 overlapped with Cz alpha. Supporting Information Figure S2 (top) shows the regional Cz alpha LocusZoom plot of the chromosome 3 region revealing high LD from about 52.2–52.8 Mb (hg19). Variants within the same region have been consistently associated with schizophrenia and bipolar disorder (Ripke et al., 2013; Sklar et al., 2011). Supporting Information Figure S2 (bottom) shows the regional association plot for the second Psychiatric Genomics Consortium schizophrenia GWAS (Ripke et al., 2014) for comparison. Top SNP in this region was rs7614727 (p = 2.0 × 10−6), which is intronic to WDR82—previously associated with bipolar disorder and schizophrenia.
