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Chunk #18 — RESULTS — Positional gene‐based analysis

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Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity.
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We performed gene‐based analysis using KGG Extended Simes test for each of the EEG traits, which combined the SNP p‐values within genes plus flanking regions 50k basepair extensions in 5′ and 3′ UTR directions while taking into account the LD structure. Q‐Q plots are included in Figure 1 (blue triangles). Plots showed inflation for gene p‐values compared to SNP p‐values. Figure 2 shows the gene‐based Manhattan plots. FDR‐corrected p‐values showed significant genes for delta, theta, and alpha power at the vertex. Supporting Information Table S2 shows the statistically significant gene discoveries (FDR q = .05).