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Chunk #17 — RESULTS — Genome‐wide association

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Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity.
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Q–Q plots for the meta‐analysis are provided in Figure 1 (pink dots). Full genome median lambdas ranged from 1.02 to 1.06. To test for inflation, we calculated LD‐score regression intercepts. These were not significant for delta, theta, and alpha oscillations and alpha peak frequency (abs(z) < 1.50); however, beta power did show significant inflation (z = 2.1). Correction of beta oscillation GWAS p‐values using the intercept had only minor effect and did not change any SNP or gene‐based results. Overall, LD score intercept results indicated that there is no evidence of substantial inflation of statistics due to, for example, residual population stratification effects.