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Chunk #16 — RESULTS — Genome‐wide association

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Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity.
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Supporting Information Figure S1 shows the Manhattan plots for the six EEG traits. Two SNPs reached genome‐wide significance (p < 5·×10−8), for Cz alpha power: (rs984924, p = 4.7 × 10−8 and rs10231372, p = 2.9 × 10−8); rs984924 on chromosome 4 is an intronic variant within protein kinase cGMP‐dependent Type II (PRKG2), and rs10231372 on chromosome 7 is an intronic variant within the long non‐coding RNA gene LINC00996. Suggestive peaks (p < 5 × 10−7) were found for Cz delta power on chromosome 5 (rs6867021, p = 1.1 × 10−7), chromosome 6 (rs17055223, p = 3.1 × 10−7), chromosome 2 (rs11677128, p = 4.3 × 10−7); Cz alpha power on chromosome 1 (rs10910665, p = 1.8 × 10−7) and on chromosome 13 (rs9514041, p = 1.4 × 10−7). Supporting Information Table S1 shows the genome‐wide significant SNPs, suggestive peaks, and FDR significant discoveries. Note that no individual SNP effects showed significant heterogeneity I 2, (nominal p > .38); however, these heterogeneity estimates are not best suited for a small number of cohorts (von Hippel, 2015).