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Chunk #31 — Results — Loss of Patterning in the Oligodendrocyte Lineage and Convergence to a Single Brain-wide Intermediate State

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Molecular Architecture of the Mouse Nervous System.
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and of the myelin oligodendrocyte glycoprotein Mog in COPs. In the spinal cord, we detected a clear expression of Hox genes 6–10 (that is, Hoxa6, Hoxb6, …, Hoxd10), which are responsible for patterning the thoracic spinal cord. These genes were expressed in spinal cord oligodendrocytes only, at levels similar to those observed in neurons and astrocytes, and they remained expressed throughout the oligodendrocyte lineage. Similarly, we found that Hox genes 1–5 (that is, Hoxa1, Hoxb1, …, Hoxc5) were expressed in the hindbrain and spinal cord oligodendrocytes, remained expressed into mature oligodendrocytes, and were expressed at levels similar to those in neurons and astrocytes.