Allele frequencies were similar to those reported in the literature and on public databases (dbSNP), shown in Table 2. None of the SNPs differed significantly from Hardy-Weinberg proportions within the groups defined by self-reported ethnicity. It is worth noting that in this region there are striking differences in allele frequencies between Caucasians and African Americans, but family-based association methods such as FBAT inherently control for population stratification. Two SNPs, rs4953 and rs35389610 were too rare (MAF < 0.006 and 0.04) to be informative in a sample of this size and so were omitted from further analyses.
