One locus achieved genome-wide significance for a single variant, as shown in the Manhattan plot in Figure 1, in which the threshold for significance, p<5×10−8, is denoted with dotted line. The top locus (chromosome 12q13.2) overlaps six genes (IKZF4, RPS26, ERBB3, PA2G4, RPL41, and ZC3H10), and is located near six additional genes (ESYT1, SUOX, RAB5B, CDK2, PMEL, and DGKA). The top SNP was rs4622308 (p=4.3×10−9, odds ratio (OR)=1.2, standard error (SE)=0.03, minor allele frequency in cases (MAFcases)=0.48, minor allele frequency in controls (MAFcontrols)=0.44). We found no evidence for heterogeneity in effect sizes across cohorts (Q=12.58, p=.32) and estimated that 12.59 percent of variation was due to heterogeneity instead of chance (I2=12.59). The effects across studies are shown in the forest plot of rs4622308 in Supplementary Figure S3.
