The results of conditional regression analyses are consistent with the existence of one signal at the top locus (see Supplementary Figure S4). The top SNP rs4622308 is in high linkage disequilibrium (LD) (r2=0.86; D’>0.99) with rs11171739, which has been found to be associated in GWASs of type 1 diabetes (20) and rheumatoid arthritis (21). The risk associated alleles of both SNPs (C–C) are typically found on the same haplotype, i.e., the direction of effect for the risk allele is consistent across anorexia nervosa and these other disorders. Several other immune-related phenotypes: vitiligo, alopecia areata, and asthma (see Supplementary Figure S5) also have associations in the region, although these are (somewhat) LD independent of rs4622308.
