percent time in center of open field) and BXD 99 (high for percent time spent in open quadrant, percent entries in open arms and percent time in center of open field, low for percent time in light in light–dark box) were identified as significant outliers (P-value < 0.05). No single strain exhibited consistently high or low values across the set of anxiety-like measures, but rather had a mix of high, intermediate or low values. Therefore, each strain may possess a unique architecture of anxiety-like behavior.