Twelve of the 21 HR-associated SNVs from the previously reported GWAS (12) were covered on the Exome Chip, either directly or by a proxy SNV in high LD (r2 > 0.8). Our discovery meta-analysis showed strong support for the previous findings, with 11 of the 12 SNVs validated at Bonferroni-adjusted significance (P ≤ 0.0042 for 12 tests), of which nine were validated at exome-wide significance (P < 2 × 10−7; Fig. 2). Only rs4140885 at the TFPI locus was not supported in our data (P = 0.10; Supplementary Material, Table S1).
