× 10−16Due to the inverse relationship between R-R interval and HR the opposite beta directions do relate to concordant directions of effect between discovery and replication. SNV, single-nucleotide variant; Chr:Pos, Chromosome:Position based on HG build 19; EA, effect allele; EAF, effect allele frequency from the discovery data; BETA-RR, beta effect estimate of RR-interval (milliseconds) taken from the ExomeRR discovery data; SE, standard error of the effect estimate; N, sample size analysed per variant (provided for genotyped discovery data only, as replication data was imputed so N = maximum N for all variants); BETA-HR, beta effect for heart rate (in beats per minute) taken from the UK Biobank replication data; P, P-value from either the discovery meta-analysis, the replication data, or the combined meta-analysis of discovery and replication data. Locus name indicates the nearest gene to the HR-associated SNV.aIndicates that the lead or a proxy SNV (r2>0.8) is a non-synonymous SNV.bIndicates if the lead SNV is predicted to be damaging. Mapping to more than 500 kb from either side of a previously reported HR-associated SNV. A novel locus is a genomic region with no SNVs in LD (r2 < 0.2) with HR-associated SNVs.
