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Chunk #1 — INTRODUCTION

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Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation.
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(QA) checks with some specialized QA tests developed for different taxa or data types. For example, all viral RefSeqs undergo taxonomic review by NCBI staff before public release. RefSeq accessions are widely cited in scientific publications and genetic databases because they provide a stable and consistent coordinate system that can be used as a baseline for reporting gene specific data, clinical variation, and cross-species comparisons. These reference sequence standards are increasingly important because accurate reporting and reproducibility are vital components for best practices in biomedical research (1).