Ten SNPs on chromosome 12 were significantly associated with the log of the average drinks/day in Korea (Baik et al., 2011). Surprisingly, they did not test rs671; all 10 SNPs are in LD with rs671 (D’ = 0.54 to 0.85), which was almost certainly driving the associations. In Japan, rs671 was very strongly associated with drinkers vs. non-drinkers (OR = 0.16, p = 3.6×10–211); the significance of other SNPs within 0.7 Mb disappeared when adjusted for rs671 (Takeuchi et al., 2011).
