Among young adult students of Asian background in the US, those with ALDH2*1/*2 drank less frequently and lower quantities of alcohol, and had fewer heavy drinking episodes and lower maxdrinks (Otto et al., 2013). In a GWAS of Americans of East Asian background, rs671 was very strongly associated with drinking status (drinking at least once per week, OR = 0.40, p = 2.3 ×10−72), but had a weaker effect on typical number of drinks per week among drinkers (p = 5.4×10−4) (Jorgenson et al., 2017); conditional analysis showed no other significant signals in the ALDH2 region.
