Despite these limitations, the current study provided empirical evidence showing that the frontal lobe and hippocampus in the triple network (SN/DMN/ECN) were particularly vulnerable to alcohol. Furthermore, we identified that the increase in FC was related to the brain's compensatory mechanism activated by structural damage. These findings provide future directions for the study of FC and structural alteration in AUDs, as potential biomarkers of disease severity and targets for therapeutic intervention.
