The HS-CC mice were the selection founders. The HS-CC was formed by interbreeding of the eight different inbred strains used to form the CC: 129Sv/Im, A/J, C57BL/6, CAST/Ei, NOD/Lt, NZO/HILt, PWK/Ph and WSB/EiJ. The intercrossing strategy was pseudo-random (Iancu et al. 2010). The HS-CC mice are maintained as 48 families using a rotational breeding scheme. The founder animals used for selection were from G23.
