Recent genetic association studies have provided evidence that polymorphisms (SNPs) in CHRNA6 and CHRNB3 are associated with nicotine dependence and subjective response to nicotine. Bierut et al (2007) and Saccone et al (2007) found SNPs upstream of CHRNB3 as well as in exon 6 (3’ UTR) of CHRNA6 to be associated with nicotine dependence in a case-control sample (Bierut et al, 2007; Saccone et al, 2007). Greenbaum et al (2006) also found association of a SNP in α6 (intron 2) with nicotine dependence in a sample of female Israeli students (Greenbaum et al, 2006). Additionally, Zeiger et al have found significant associations between SNPs located in the upstream region of CHRNB3 and in exon 6 of the CHRNA6 gene and subjective responses to nicotine, in separate samples of selected and community young adults (Zeiger et al, 2008). To the best of our knowledge, association of CHRNA6 and CHRNB3 with dependence measured by DSM-IV has not been reported, nor has quit attempts been examined. In an effort to strengthen these recent findings as relevant to the general U.S. population, we present
