The findings for the multivariate IPTW logistic regression models are presented in Table 3. The analyses were completed for the entire study sample, and separately within specific strata. For example, in the sex-stratified analyses, we ran models separately for males and females. The adjusted analyses took into account the IPTW, and adjusted for sociodemographic, psychopathology, and treatment history covariates. For the total sample, self-medication of mood symptoms with alcohol was associated with an increased odds for incident alcohol dependence during follow-up (adjusted odds ratio [AOR]=3.10, 95% confidence interval [CI]=1.55-6.19, p=0.002), and for persistent alcohol dependence (AOR=3.45, CI=2.35-5.08, p<0.001). The proportion of incident alcohol dependence cases attributable to alcohol self-medication in the population, taking into account survey weights, was approximately 12% (PAF=11.9%, CI=6.7-16.9%). However, 30.6% (CI=24.8-36.0%) of persistent alcohol dependence cases can be attributable to drinking to self-medicate mood symptoms.
