Chunk #18 — MATERIALS AND METHODS — Electrophysiology analysis — Fast and slow potassium currents

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Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium.

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The fast potassium current has been shown to be related to the A-type potassium channels.54 We measured the fast potassium current by the maximum current immediately following a depolarization step, typically within a time window of a few milliseconds. The slow potassium currents were obtained at the end of the 400 ms depolarization step and have been shown to be related to the delayed rectifier potassium channels.54