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Chunk #37 — Methods — UK Brain Expression Consortium (UKBEC)

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Transcriptomic signatures of brain regional vulnerability to Parkinson's disease.
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UKBEC20 (http://www.braineac.org) contains microarray expression data from 10 brain regions of 134 non-neurological donors (74.5% males, mean age 59, range 16–102 years) for which their control status was confirmed by histology. We used the biomaRt R-package version 2.3847 to map Affymetrix probe IDs from UKBEC to gene Entrez IDs; 262,134 out of 318,197 probes could be mapped. Similar as with the AHBA, expression data for all probes and samples was concatenated across the 10 brain regions before mapping probes to 18,333 genes with unique Entrez IDs using the collapseRows-function.