The Fisher transformation (Fisher, 1915) was applied to all rsFNC values prior to statistical testing. Age and sex differences were regressed out for each rsFNC along the subject dimension. The rsFNC matrices were then organized into the four groups: CTR, DRN, SMK and SAD. Group differences were evaluated for each rsFNC pair using one-way ANOVA. Statistical significance for each ANOVA was assessed at the p < 0.05 level and corrected using false discovery rate (FDR) multiple comparison correction. Post hoc analyses based on the Fisher's least significant difference procedure (Hayter, 1986) were applied to those ANOVA results surviving FDR correction.
