The rsFNCs with significant group differences, tested using one-way ANOVA, were further analyzed for significant relationship with AUDIT and FTND variables. A regression model was implemented separately for different sample groups, where the original Fisher transformed rsFNC data was utilized as the dependent variable for each of the regression models, and confounding factors sex, age, BDI, ImpSS and income were included as independent variables. FTND as an additional independent variable was included for subjects in the SMK group. AUDIT was similarly tested for the DRN group. In the case of the SAD group, the interaction between AUDIT and FTND was added.