reported an association of CTBP2 and DSM-IV Alcohol Dependence in an Australian cohort of 1,224 cases and 1,162 controls, although the association did not meet genome-wide significant criteria (p-value: 3.91×10−7;(Lind et al., 2010)). Further support for the role of CTBP2 in alcohol related behavior comes from model organism work (Grotewiel and Bettinger, 2015); a genetic screen in nematode Caenorhabditis elegans identifies ctbp-1 (the ortholog of CTBP2) as a key regulator required for the development of acute functional tolerance to ethanol (Bettinger et al., 2012; Reid et al., 2015). While this previous literature lends corroborating support for the association of CTBP2 and AUD reported here, this finding should clearly be replicated in independent, larger samples.
