CTBP2 is from a family of COOH-terminal binding proteins (CtBPs), which are widely expressed during several developmental processes, and have been linked to various complex traits, including cancers and Alzheimer’s disease (Liu et al., 2014; Zhang et al., 2014; Zheng et al., 2015). Importantly, two previous studies have found associations among CTBP2 and alcohol related phenotypes. A linkage analysis of alcohol and cigarette consumption (maximum cigarettes/grams of alcohol consumed per day) conducted in 1,390 individuals from 41 extended Mexican American families indicated a linkage peak on Chromosome 10. Subsequently, an expression profile analyses of 342 RNA transcripts under the linkage peak pointed to two genes, one of which was CTBP2. Further, CTBP2 was shown to influence RNA levels, which was negatively correlated with smoking and/or drinking (Viel et al., 2008). In addition, an early GWAS of alcohol and nicotine dependence reported an association of CTBP2 and DSM-IV Alcohol Dependence in an Australian cohort of 1,224 cases and 1,162 controls, although the association did not meet genome-wide significant criteria (p-value: 3.91×10−7;(Lind et al., 2010)). Further support for the role of CTBP2
