In evaluating genetic differences between cannabis and control subjects in regard to the DRD2 and PENK genes, it was observed that several DRD2 and PENK SNPs studied modulated cannabis-dependence outcomes ( Table 2 ). A strong association was evident between the PENK SNP rs2576573 and cannabis-dependence diagnoses; 61.7% of cannabis-dependent subjects were A/G carriers, compared with 29.2% of controls (p<0.001). Similar findings were apparent for the other PENK SNP rs2609997 and the DRD2 SNP rs6277. Only the association between cannabis dependence and the two PENK SNPs remained significant after Bonferroni correction.
