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coga / coga-kb
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Chunk #6 — Methods — Locus conservation

Source
Obesity-associated variants within FTO form long-range functional connections with IRX3.
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yes

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Similarly, in the FTO/IRX5 interval, 9% of the base pairs have phastCons score above 0.9 (range: 0.0–1.0), whereas 14,164 intervals from all chromosomes of the same size offset by 200kb contain only 3.8% +− 1.9 of such high-scoring base pairs. At 9%, the FTO/IRX5 is at the top 2% intervals with the most conserved base pairs.