with higher folding in a right lateral occipital region and at a trend level for the left dorsolateral prefrontal cortex. Controls did not show an association. The findings suggest a role of NCAN in visual processing and top-down cognitive functioning. Both major cognitive processes are known to be disturbed in schizophrenia. Another GWAS study by Rietschel et al. (2012) identified a risk factor for schizophrenia in a chromosomal region harboring the genes AMBRA1/CHRM4/DGKZ/MDK (rs11819869). In an independent follow-up analysis, they found that healthy carriers of the risk allele T showed altered activation in the subgenual cingulate cortex during a cognitive control task. This brain region is a critical interface between emotion regulation and cognition, which are structurally and functionally abnormal in schizophrenia and bipolar disorder.
