For rs116628628, the minor allele of the rare variant was observed more frequently in OD cases than in controls at the sequencing stage. However, the difference was not observed at the genotyping stage. Thus, it is likely that rs116628628 has little actual effect on OD risk and its inclusion did not contribute to the association signal. As stated above, without considering rs116628628, the association p-value for the combined sample was 0.0001. However, after including this rare variant, the p-value increased to 0.0010. Because we followed-up three DISC1 rare variants, we included all of them in the association test.
