The above details RV support for DISC1 association with OD. We have also reported common-variant support, for variants at the same risk locus: in our GWAS for OD, DISC1 was identified as a possible risk locus, based on supporting evidence in both EAs and AAs (Gelernter et al, submitted manuscript). We believe that the presence of both rare and common variants at the same locus associated with risk for the same trait, adds greatly to the overall support for association, although naturally replication by other research groups is necessary.
