The sample in the current study was drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), a decades-long longitudinal national project following families affected with AUD and comparison families in a carefully characterized enriched family sample with data collection in multiple domains to investigate biological mechanisms underlying risk, development and consequences of alcohol addiction (Agrawal et al., 2023; Ehringer, 2023; Johnson et al., 2023; Kinreich et al., 2021b; Meyers et al., 2023).