In this project, we sought to determine whether PAC significantly differs between AUD and unaffected control groups, and if so, to confirm and characterize the phase-amplitude (PA) frequency pair domains where significant PAC differences were found. Our understanding of the neurophysiological, genetic, and environmental underpinnings of AUD has benefited greatly over the past several decades from large scale family-based datasets, like the Collaborative Study on the Genetics of Alcoholism (COGA), collecting multi-modal longitudinal data from families afflicted by AUD (Agrawal et al., 2023; Dick et al., 2023; Johnson et al., 2023). EEG resting state data drawn from COGA participants was used to compare resting state PAC estimates between those with severe AUD (DSM-5, 6+ symptoms) and unaffected controls. We focused on the frontomedial EEG channel FZ to illuminate any possible associations between AUD and PAC in the mPFC.
