After we observed that cis-eQTLs replicated between whole blood datasets (Supplementary Figure 1a), we investigated the replicability of cis-eQTLs in other tissues. In 47 postmortem tissues (Genotype Tissue Expression (GTEx) data)18, we observed an average replication rate of 14.8% (discovery analysis without GTEx, Benjamini-Hochberg FDR<0.05 in GTEx; median across tissues 15.0%, range 3.6–29.6% when excluding whole blood) and, on average, a 94.9% concordance in allelic directions (median 95.2%, range 86.7–99.2%, when excluding whole blood) among the cis-eQTLs for which the lead SNP effect replicated in GTEx (Supplementary Note, Extended Data Figure 1 and Supplementary Data 1).
