The lifetime prevalence of comorbid SUD in this Latino sample of subjects with SC was on the low end compared to rates documented in previous studies from Europe and non-Latino US populations (Cantor-Graae et al., 2001). However, the prevalence rates of comorbidity varied among Latinos based on the country they were living in. Latinos living in the US had lifetime rates of DD similar to what has described for SC subjects in the US (Cantor-Graae et al., 2001; Kessler et al., 2005; Regier et al., 1990). In contrast, Latinos living in Central America and Mexico had much lower rates of comorbid SUD, which were comparable with studies of with DD in Latino populations (Montross et al., 2005; Vega et al., 2006).