invokes another agent to query Ensembl Protein Report (16) and obtain all known alternative spliced-form mRNAs for the gene where the SNP is located. With the spliced form mRNAs, the agent for SwissProt (15) will be able to extract the data about the translated proteins of the mRNAs to determine if the SNP leads to an alternative splicing that abolishes a protein domain. FASTSNP will perform the necessary post-processing for the data returned from the agent pipelines and submit the results to the prioritization module, which will then classify the SNP, assign it a risk ranking according to the decision tree shown in Figure 1, and compile the results into a function report.
