were pretreated with saline and conditioned with ethanol in young adulthood. Additionally, adolescent rats that were treated with ethanol and subsequently conditioned with ethanol in young adulthood demonstrated a greater amount of time spent in the ethanol-paired chamber relative to animals pretreated with ethanol and conditioned with saline during young adulthood (Figure 3; Maldonado, Badanich, and Kirstein, unpublished data). These data indicate animals exposed to ethanol during adolescence and re-exposed to ethanol in adulthood showed greater ethanol-seeking behavior manifested as increased time spent in the drug-paired chamber relative to animals exposed to ethanol for the first time in adulthood.
