Because there was no strong replication signal in non-blood tissues and the majority of eQTSs were observed for blood-related traits, we speculate that these effects are highly tissue- or cell-type-specific and that eQTS analysis would yield the most informative results if conducted in the trait-relevant tissue. However, power analyses suggest that the limited replication in other tissues could also be the result of a lack in statistical power explained by the small effect sizes of eQTSs (Supplementary Figure 8i) and moderately sized replication datasets.
