Chunk #16 — Do cannabinoids cause short-lived positive psychotic symptoms, negative symptoms and cognitive deficits in the general population? — Positive symptoms
Δ9-THC induced a range of positive symptoms of schizophrenia, including suspiciousness, paranoid and grandiose delusions, conceptual disorganization, fragmented thinking, and perceptual alterations. For example, healthy controls reported suspiciousness such as “I thought you all were trying to trick me by changing the rules of the tests to make me fail. I thought you were turning the clock back to confuse me,” or “I thought that this was real….I was convinced this wasn’t an experiment,” or “I thought you all were giving me THC through the BP (blood pressure) machine and the sheets”. Healthy controls also reported conceptual disorganization such as “I couldn’t keep track of my thoughts… they’d suddenly disappear,” or “It seemed as if all the questions were coming to me at once… everything was happening in staccato,” or “my thoughts were fragmented… the past present and future all seemed to happening at once.” Healthy subjects also reported unusual thoughts such as “I thought you could read my mind, that’s why I didn’t answer… I felt as if my mind was nude,” or “I felt I could see into