Chunk #4 — Introduction

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A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study.

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led to successfully genotyping of over 1,500 SNPs. This together with imputation into the updated 1000 Genomes Project allowed us to densely fine-mapping this region. In addition, we performed a detailed bioinformatic analysis to propose candidate polymorphisms for follow-up functional evaluation.