There was not support for specific (q < 0.5) variants in another sample assessed for comparable alcohol use phenotypes. Such failures to replicate may be due to population-specific effects (genetic and/or environmental) or false positive results. Many markers with q < 0.5 in the current analyses were assayed only in the AFR ancestry group due to low MAC in other groups. These results underscore the need for additional genetic analyses to be conducted in samples of non-European ancestry, not only to facilitate replication, but also to clarify potential differences in genetic risk factors across ancestries (Dick et al., 2017).
