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Chunk #41 — Discussion

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Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.
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Our results examining the heritability of childhood-onset OCD are in line with previous studies that suggest a higher heritability for childhood-onset OCD than for adult onset OCD. However, because of the smaller sample sizes due to splitting the OCD sample into two groups based on age of onset, the 95% confidence intervals for childhood-onset and adult-onset OCD overlap, and are not significantly different from each other. With increased sample sizes it may be possible to confirm these observed heritability differences and to obtain more precise estimates of the relative heritability of child and adult onset OCD.