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Chunk #40 — Discussion

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Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.
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Figure S8). The result is intriguing especially considering that the non-eQTL partition contained over 6.5 million SNPs, approximately twelve times the number of SNPs contained in the brain-only eQTL partition. These findings are preliminary and will require replication. Nevertheless, when interpreted in the context of additional recent studies showing specific enrichment of brain eQTLs in top GWAS signals from neuropsychiatric phenotypes, our results suggest that further study of the role of brain eQTLs in TS and OCD is warranted [61], [38].