Finally, we evaluated the influence of these four factors in vivo using a nude mice glioma xenograft model. As shown in Figure 8A, nude mice in the groups injected with TAF15+, LINC00665+, MTF1−, and YY2− glioma cells developed smaller tumors compared with those of the control group. Furthermore, the TAF15+ + LINC00665+ + MTF1− and TAF15+ + LINC00665++YY2− groups had the smallest tumor volumes overall (Figure 8B). The survival analysis indicated that mice in all of the treatment groups achieved longer survival than did those in the control group, although the nude mice in the TAF15+ + LINC00665+ + MTF1− and TAF15+ + LINC00665++YY2− groups showed the longest survival time (Figure 8C). Furthermore, we evaluated the influence of GTSE1 knockdown in vivo and found that nude mice in the groups injected with GTSE1− glioma cells developed smaller tumors and gained longer survival time than did those in the control group (Figures S5A–S5C).
