Four of the newly associated loci (rs16857609 at 2q35, rs10759243 at 9q31, rs11199914 at 10q26 and rs2588809 at 14q24) lie close to regions previously associated with breast cancer risk. In each locus, however, the lead SNP was not correlated with the most strongly associated known association, and the association of the new SNP remained similarly statistically significant after adjustment for the previously associated SNP (Supplementary Table 5). In the case of rs2588809, which lies in RAD51B (also known as RAD51L1), the association was markedly stronger for ER-positive disease (P = 0.011; Supplementary Table 7a), whereas the previously associated SNPs (rs999737 and rs10483813), which lie ~370 kb telomeric, are associated with similar ORs for both ER-positive and ER-negative disease26.
