Our study has several limitations. Our analyses focused on individuals with European ancestry in order to avoid confounding from population substructure and admixture. We performed several analyses to assess the generalizability to individuals of diverse and admixed genetic ancestry but much larger samples are needed to address this important aspect. Another basic limitation is that still most of the risk loci remain to be discovered and scrutinized to inform on the pathophysiology. Additionally, studies in clinical settings are needed to assess the clinical utility of our findings.
